Página web de difusión de resultados del proyecto de investigación CTQ2009-11501: "Metalociclos con ligandos N-dadores: Sensores e interruptores moleculares, compuestos hidrosolubles y de interés biológico"

Índice

Publicaciones derivadas del proyecto (títulos en verde reviews).


44. A combined kinetico-mechanistic and computational study on the competitive formation of seven- versus five-membered platinacycles; the relevance of spectator halide ligands. Gabriel Aullón, Margarita Crespo, Mercè Font-Bardia, Jesús Jover, Manuel Martínez and Jack Pike. Dalton Trans., 2015, 44, 17968.
43. Heterodi- (Fe, Pd/Pt) and Heterotrimetallic (Fe2, Pd) Complexes Derived from 4-(Ferrocenylmethyl)-N-(2-methoxyethyl)-3,5-diphenylpyrazole as Potential Antitumoral Agents. Eva Guillén, Asensio González, Concepción López, Pradipta K. Basu, Amrita Ghosh, Mercè Font-Bardía, Carme Calvis, and Ramón Messeguer. Eur. J. Inorg. Chem. 2015, 3781–3790.
42. Cyclopalladated Benzophenone Imines: Synthesis, Antitumor Activity, Cell Accumulation, DNA Interaction, and Cathepsin B Inhibition. Joan Albert, Jaume Granell, Romana Qadir, Josefina Quirante, Carme Calvis, Ramon Messeguer, Josefa Badía, Laura Baldoma, Merce  Font-Bardia, and Teresa Calvet. Organometallics 2014, 33, 7284−7292.
41. Kinetico-mechanistic studies on C-X (X = H, F, Cl, Br, I) bond activation reactions on organoplatinum(II) complexes. Margarita Crespo, Manuel Martínez, S. Masoud Nabavizadeh, Mehdi Rashidi. Coordination Chemistry Reviews 279 (2014) 115–140.
40. Catalytic C−H Activation of Phenylethylamines or Benzylamines and Their Annulation with Allenes. Aleix Rodríguez, Joan Albert, Xavier Ariza, Jordi Garcia, Jaume Granell, Jaume Farràs, Andrea La Mela, and Ernesto Nicolás. J. Org. Chem. 2014, 79, 9578-9585.
39. Cyclopalladated primary amines: A preliminary study of antiproliferative activity through apoptosis induction. Joan Albert, Ramon Bosque, Margarita Crespo, Graciela García, Jaume Granell, Concepción López, María Victoria Lovelle, Romana Qadir, Asensio González, Anusha Jayaraman, Enric Mila, Roldán Cortés, Josefina Quirante, Carme Calvis, Ramon Messeguer, Josefa Badía, Laura Baldom, Marta Cascante. European Journal of Medicinal Chemistry 84 (2014) 530-536.
38. Cyclopalladated and cycloplatinated benzophenone imines: Antitumor, antibacterial and antioxidant activities, DNA interaction and cathepsin B inhibition. Joan Albert, Lucía D'Andrea, Jaume Granell, Pepita Pla-Vilanova, Josefina Quirante, Muhammad Kaleem Khosa, Carme Calvis, Ramon Messeguer, Josefa Badía, Laura Baldomà, Mercè Font-Bardia, Teresa Calvet. Journal of Inorganic Biochemistry 140 (2014) 80-88.
37. Diarylplatinum(II) Compounds as Versatile Metallating Agents in the Synthesis of Cyclometallated Platinum Compounds with N-Donor Ligands. Margarita Crespo. Inorganics 2014, 2, 115-131.
36. Pd(II) complexes with N-substituted pyrazoles as ligands. The influence of the R group [OMe versus NMe2] of [1-{R-(CH2)2-}-3,5-Ph2-(C3HN2)] on their cytotoxic activity on breast cancer cell lines. John U. Chukwu, Concepción López, Asensio González, Mercè Font-Bardía, M. Teresa Calvet, Ramon Messeguer, Carme Calvis. Journal of Organometallic Chemistry 766 (2014) 13-21.
35. Exploring the Scope of [Pt2(4-FC6H4)4(μ-SEt2)2] as a Precursor for New Organometallic Platinum(II) and Platinum(IV) Antitumor Agents. Anna Escola, Margarita Crespo, Josefina Quirante, Roldán Cortés, Anusha Jayaraman, Josefa Badía, Laura Baldoma, Teresa Calvet, Merce  Font-Bardía, and Marta Cascante. Organometallics 2014, 33, 1740-1750.
34. New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity. Joan Albert, Ramon Bosque, Magali Cadena, Lucía D’Andrea, Jaume Granell, Asensio González, Josefina Quirante, Carmen Calvis, Ramon Messeguer, Josefa Badía, Laura Baldoma, Teresa Calvet, and Mercè Font-Bardia. Organometallics 2014, 33, 2862-2873.
33. A novel cyclometallated Pt(II)–ferrocene complex induces nuclear FOXO3a localization and apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation. Roldán Cortés, Míriam Tarrado-Castellarnau, Daniel Talancón, Concepción López, Wolfgang Link, Daniel Ruiz, Josep Joan Centelles, Josefina Quirante and Marta Cascante. Metallomics, 2014, 6, 622. 
32. Platinum(II) Compounds Containing Cyclometalated Tridentate Ligands: Synthesis, Luminescence Studies, and a Selective Fluoro for Methoxy Substitution. Albert Gandioso, Jennifer Valle-Sistac, Laura Rodríguez, Margarita Crespo, and Merce Font-Bardia. Organometallics 2014, 33, 561−570.
31. Diastereomerically Pure Heterodi- and Heterotetrametallic (Pd and Pt) Compounds: A Study of the Effect Induced by the Binding Mode of a Ferrocene-Containing Ligand on Their Electrochemical Properties. Daniel Talancón, Concepción López, Mercè Font-Bardía, Teresa Calvet, and Olivier Roubeau. Eur. J. Inorg. Chem. 2014, 213–220.
30.  Regioselective C−H Activation Preceded by Csp2−Csp3 Reductive Elimination from Cyclometalated Platinum(IV) Complexes. Craig M. Anderson, Margarita Crespo, Nicole Kfoury, Michael A. Weinstein, and Joseph M. Tanski. Organometallics 2013, 32, 4199−4207.
29. Neutral and Ionic Cycloruthenated 2‑Phenylindoles as Cytotoxic Agents. Lluís Belsa, Concepción López, Asensio Gonzáĺez, Merce  Font-Bardia, Teresa Calvet, Carmen Calvis, and Ramon Messeguer. Organometallics 2013, 32, 7264−7267. 
28. Trans- and cis-2-phenylindole platinum(II) complexes as cytotoxic agents against human breast adenocarcinoma cell lines. Maria Tomé, Concepción López, Asensio González, Bahadir Ozay, Josefina Quirante, Mercè Font-Bardía, Teresa Calvet, Carme Calvis, Ramon Messeguer, Laura Baldomá, Josefa Badía.  Journal of Molecular Structure 1048 (2013) 88-97.
27. Pt(II) complexes with (N,N') or (C,N,E) (E = N,S) ligands: Cytotoxic studies, effect on DNA tertiary structure and structure–activity relationships. Joan Albert, Ramon Bosque, Margarita Crespo, Jaume Granell, Concepción López, Roldán Cortés, Asensio Gonzalez, Josefina Quirante, Carme Calvis, Ramon Messeguer, Laura Baldomà, Josefa Badia, Marta Cascante. Bioorganic & Medicinal Chemistry  21 (2013) 4210-4217.
26. Hemilabile and luminescent palladium(II) azo-2-phenylindole complexes. Asensio González, Jaume Granell, Concepción López, Ramon Bosque, Laura Rodríguez, Mercè Font-Bardia, Teresa Calvet, Xavier Solans. Journal of Organometallic Chemistry 726 (2013) 21-31.
25. NH2 As a Directing Group: From the Cyclopalladation of Amino Esters to the Preparation of Benzolactams by Palladium(II)-Catalyzed Carbonylation of N-Unprotected Arylethylamines. Joan Albert, Xavier Ariza, Teresa Calvet, Mercé Font-Bardia, Jordi Garcia, Jaume Granell, Andrea Lamela, Blanca López, Manuel Martinez, Laura Ortega, Aleix Rodriguez, and David Santos. Organometallics 2013, 32, 649-659.
24. Cyclopalladated benzophenone imines: synthesis, cytotoxicity against human breast adenocarcinoma cell lines and DNA interaction. Joan Albert, Silvia García, Jaume Granell, Albert Llorca, María Victoria Lovelle, Virtudes Moreno,  Andreu Presa, Laura Rodríguez,  Josefina Quirante, Carme Calvis, Ramon Messeguer, Josefa Badía, Laura Baldomà. Journal of Organometallic Chemistry 724 (2013) 289-296.
23. New Insights in the Formation of Five- Versus Seven-Membered Platinacycles: A Kinetico-Mechanistic Study. Paul V. Bernhardt, Teresa Calvet, Margarita Crespo, Merce  Font-Bardía, Susanna Jansat, and Manuel Martínez. Inorg. Chem. 2013, 52, 474 - 84.
22. Diastereomerically pure platinum(II) complexes as antitumoral agents. The influence of the mode of binding {(N), (N,O)− or (C,N)}− of (1S,2R)-[(η5-C5H5)Fe{(η5-C5H4)-CH=N-CH(Me)-CH(OH)-C6H5}] and the arrangement of the auxiliary ligands. Daniel Talancón, Concepción López, Mercè Font-Bardía, Teresa Calvet, Josefina Quirante, Carme Calvis, Ramon Messeguer, Roldán Cortés, Marta Cascante, Laura Baldomà, Josefa Badia. Journal of Inorganic Biochemistry 118 (2013) 1 - 12.
21. Kinetico-Mechanistic Studies on Intramolecular C–X Bond Activation (X = Br, Cl) of Amino-Imino Ligands on Pt(II) Compounds. Prevalence of a Concerted Mechanism in Nonpolar, Polar, and Ionic Liquid Media. Teresa Calvet, Margarita Crespo, Mercè Font-Bardía, Susanna Jansat, and Manuel Martínez. Organometallics, 2012, 31, 4367 - 4373.
20. Reductive Elimination from Cyclometalated Platinum(IV) Complexes To Form Csp2–Csp3 Bonds and Subsequent Competition between Csp2–H and Csp3–H Bond Activation. Margarita Crespo, Craig M. Anderson, Nicole Kfoury, Mercè Font-Bardia, and Teresa Calvet. Organometallics, 2012, 31, 4401 - 4404.
19. Seven-membered cycloplatinated complexes as a new family of anticancer agents. X-ray characterization and preliminary biological studies. Roldán Cortés, Margarita Crespo, Laia Davin, Raquel Martín, Josefina Quirante, Daniel Ruiz, Ramon Messeguer, Carme Calvis, Laura Baldomà, Josefa Badia, Mercè Font-Bardía, Teresa Calvet, Marta Cascante. European Journal of Medicinal Chemistry 54 (2012) 557 - 566.
18. Insertion of Symmetric Alkynes into the σ[Pd–C(sp2, Ferrocene)] Bond of Palladacycles with [C(sp2, Ferrocene),N,S(Thienyl)]– Pincer Ligands. Concepción López, Mauro Salmi, Antoni Mas, Piotr Piotrowski, Mercè Font Bardía, and Teresa Calvet. Eur. J. Inorg. Chem. 2012, 1702 - 1709.
17. Platinum(II) and palladium(II) complexes derived from 1-ferrocenylmethyl-3,5-diphenylpyrazole. Coordination, cyclometallation or transannulation? Concepción López, Asensio González, Ramon Bosque, Pradipta K. Basu, Mercè Font-Bardia and Teresa Calvet. RSC Advances, 2012, 2, 1986 - 2002.
16. Fluorine in Cyclometalated Platinum Compounds. Margarita Crespo. Organometallics 2012, 31, 1216 - 234.
15. A New Cyclometalation Motif: Synthesis, Characterization, Structures, and Reactivity of Pallada- and Platinacycles with a Bidentate {C(sp2,cyrhetrene),N} Ligand. Teresa Cautivo, Hugo Klahn, Fernando Godoy, Concepción López, Mercè Font-Bardía, Teresa Calvet, Enrique Gutierrez-Puebla, and Angeles Monge. Organometallics 2011, 30, 5578 - 5589.
14. Platinum(II) and palladium(II) complexes with (N,N′) and (C,N,N′)− ligands derived from pyrazole as anticancer and antimalarial agents: Synthesis, characterization and in vitro activities. Josefina Quirante, Daniel Ruiz, Asensio Gonzalez, Concepción López, Marta Cascante, Roldán Cortés, Ramon Messeguer, Carme Calvis, Laura Baldomà, Aurélie Pascual, Yann Guérardel, Bruno Pradines, Mercè Font-Bardía, Teresa Calvet, Christophe Biot. Journal of Inorganic Biochemistry 105 (2011) 1720 - 1728.
13. Biaryl formation in the synthesis of endo and exo-platinacycles. Margarita Crespo, Mercè Font-Bardia, and Teresa Calvet. Dalton Trans., 2011, 40, 9431 - 9438.
12. Synthesis of Cyclopalladated Derivatives of (E)-N-Benzylidene-2-(2,6-dichlorophenyl)ethanamine and Their Reactivity towards Monodentate and Symmetric Bidentate Lewis Bases. Joan Albert, Ramón Bosque, Lucía D’Andrea, Jaume Granell, Mercè Font-Bardia, and Teresa Calvet. Eur. J. Inorg. Chem. 2011, 3617 - 3631.
11. Synthesis, crystal structures and properties of cis- and trans-isomers of [Pt{C6H4-4R1-1-[C8H4N-3’-NOMe]}Cl2(dmso)] (R1 = H or Cl). Concepción López, Carlos Moya, Pradipta K. Basu, Asensio González, Xavier Solans, Mercè Font-Bardía, Teresa Calvet, Elena Lalinde, M. Teresa Moreno. Journal of Molecular Structure 999 (2011) 49 - 59.
10. Ferrocene-indole hybrids for cancer and malaria therapy. Josefina Quirante, Faustine Dubar, Asensio González, Concepción Lopez, Marta Cascante, Roldán Cortés, Isabelle Forfar, Bruno Pradines, Christophe Biot. Journal of Organometallic Chemistry 696 (2011) 1011 - 1017. 
9. Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines. Blanca López, Aleix Rodriguez, David Santos, Joan Albert, Xavier Ariza, Jordi Garcia and Jaume Granell. Chem. Commun., 2011, 47, 1054 - 1056.
8. Study of the Effect Induced by the Substituents on the Ring-Chain Tautomerism of Schiff Bases Derived from Norephedrine. Daniel Talancón, Ramon Bosque, and Concepción López. J. Org. Chem. 2010, 75, 3294 - 3300.
7. Platinum-Mediated C-H Bond Activation of Arene Solvents and Subsequent C-C Bond Formation. Joan Albert, Ramon Bosque, Margarita Crespo, Jaume Granell, Judit Rodríguez, and Javier Zafrilla. Organometallics 2010, 29, 4619 - 4627.
6. Platinum-mediated aryl–aryl bond formation and sp3 C–H bond activation. Margarita Crespo, Teresa Calvet and Mercè Font-Bardia. Dalton Trans., 2010, 39, 6936 - 6938.
5. Synthesis and Reactivity of Coordination and Six-Membered, Cyclometalated Platinum Complexes Containing a Bulky Diimine Ligand. Craig M. Anderson, Margarita Crespo, and Joseph M. Tanski. Organometallics 2010, 29, 2676 - 2684.
4. Cyclopalladation of Schiff Bases from Methyl Esters of a-Amino Acids. Unexpected Activation of the O-Me Bond with Formation of a Bianionic Tridentate Metallacycle. Joan Albert, Margarita Crespo, Jaume Granell, Judit Rodríguez, Javier Zafrilla, Teresa Calvet, Mercè Font-Bardia, and Xavier Solans. Organometallics 2010, 29, 214 - 225.
3. Influence of the substituent R1 on the reactivity of [(h5-C5H5)Fe{(h5-C5H4)–CH=N–(R1)–OH}] {R1 = –CH2–CH2– or 1,2-C6H4} with platinum(II) and on the properties of the complexes. Concepción López, Sonia Pérez, Xavier Solans, Mercè Font-Bardia and Teresa Calvet. New J. Chem., 2010, 34, 676 - 685.
2. Study on the Lability of the σ(Pd–S) Bond of Novel Palladacycles with [C(sp2,ferrocene),N,S(thienyl)]– Pincer Ligands. David Pou, Concepción López, Sonia Pérez, Xavier Solans, Mercè Font-Bardia,  Piet W. N. M. van Leeuwen, and Gino P. F. van Strijdonck. Eur. J. Inorg. Chem. 2010, 1642 - 1648.
1. 1-Methyl-4-ferrocenylmethyl-3,5-diphenylpyrazole: A versatile ligand for palladium(II) and platinum(II). Pradipta Kumar Basu, Asensio González, Concepción López, Mercè Font-Bardia, Teresa Calvet. Journal of Organometallic Chemistry 694 (2009) 3633 -  3642.