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Intramolecular
C-X activation in molecular compounds of
Mn(I) (X = H or Cl), Ru(II) (X = H), Ni(0) (X
= F, Cl or Br), Pd(0) (X = Cl), Pd(II) (X = H or O), Pt(0) (X
= H, F, Cl or Br) and Pt(II) (X = H, F, Cl, Br
or I): Applications in organometallic and
organic synthesis. Developed in
collaboration with Drs J. Sales, G. Muller, R. M.
Ceder, C.
López, A. Grabulosa, D. Sainz (Inorganic
Chemistry Section UB), M. Gómez (Université Tolouse-3, Paul
Sabatier), C. Anderson (Bard
College), and A. González (Department of Organic
Chemistry, Pharmacy Faculty UB).
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Crystal
structures of cyclometallated compounds
and related compounds. Developed in collaboration with
Drs X. Solans
(Crystallography Department UB), M. Font-Bardia
(Scientific-Technical Services UB), C. Puerta,
P. Valerga (Cádiz University), L. Barrios (Inorganic
Chemistry Section UB),
and M. C.
Puigjaner (Scientific-Technical Services UB).
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Reactions of cyclometallation
at Pd(II) and Pt(II) centres and
of oxidative addition at Pt(II) centres:
Reaction kinetics and activation
parameters. Developed in collaboration with Dr M. Martínez (Inorganic Chemistry Section UB).
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Optical resolution of
chiral phosphines by optically active
cyclometallated palladium(II) compounds.
Developed in collaboration with Drs G. Muller, D. Sainz and M.
Rocamora (Inorganic Chemistry
Section UB).
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Electrochemistry of Pt(II) and Pt(IV) cyclometallated compounds.
Developed
in collaboration with Drs A.
Klein (Institut für Anorganische Chemie der
Universität Stuttgart) and C. López (Inorganic Chemistry
Section UB).
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Computational
studies: Optimization of: i) the geometry
of Pd(II), Pt(II) and Pt(IV) molecular
compounds, and
ii) cyclometallation reactions transition
states.
Developed in collaboration with
Drs R. Bosque, G. Aullón
and J. Jover (Inorganic Chemistry
Section UB).
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Catalytic
functionalization of C-H bonds by
directing groups and Pd(0) or Pd(II)
catalysts. Developed in
collaboration with
Drs J. García, X. Ariza, E.
Nicolás and J. Farrŕs (Organic
Chemistry Section UB).
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Cyclometallated
Pd(II), Pt(II) and Pt(IV) compounds:
Cytotoxicity.
Developed in collaboration with Drs M. Cascante
(Biochemistry and Molecular Biomedicine
Department UB), R. Messeguer (LEITAT) and J.
Quirante (Pharmacology, Toxicology and
Therapeutic Chemistry Department UB). Cell cycle
arrest, apoptosis and ROS
(reactive oxygen species). Developed in collaboration with Drs M. Cascante (Biochemistry and Molecular
Biomedicine Department UB) and J.
Quirante (Pharmacology,
Toxicology and Therapeutic Chemistry
Department UB). Interaction
with DNA and enzymes. Developed in
collaboration with Drs L. Baldomŕ and
J. Badia (Biochemistry and Physiology Department
UB) and J. Quirante (Pharmacology, Toxicology and
Therapeutic Chemistry Department UB).
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Luminescent
Pt(II)
and Pt(IV)
cyclometallated compounds.
Developed
in collaboration with Dr
L. Rodríguez (Inorganic Chemistry
Section UB).
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Pd(II) cyclometallated compounds
antibacterial and
antioxidant activity in vitro.
Developed in
collaboration with Dr K. Khosa (GC University Faisalabad).
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Application
of imine cyclometallated Ru(II) and Pd(II) compounds in
catalysis. Developed
in collaboration with Drs A. Grabulosa and D. Sainz (Inorganic Chemistry
Section UB).
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