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Organometallic chemistry: synthesis and applications of cyclometallated compounds
Research lines and collaborations (in green active research lines and collaborations)
 
  • Intramolecular C-X activation in molecular compounds of Mn(I) (X = H or Cl), Ru(II), (X = H), Ni(0) (X = F, Cl or Br), Pd(0) (X = Cl), Pd(II) (X = H or O), Pt(0) (X = H, F, Cl or Br) and Pt(II) (X = H, F, Cl, Br or I): Applications in organometallic and organic synthesis. Developed in collaboration with Drs J. Sales, G. Muller, R. Ceder (Inorganic Chemistry Department UB), C. López (Inorganic Chemistry Section UB), C. Anderson (Bard College), A. González (Department of Organic Chemistry, Pharmacy Faculty UB) and A. Grabulosa (Inorganic Chemistry Section UB).
  • Crystal structures of cyclometallated compounds and related compounds. Developed in collaboration with Drs M. Font-Bardia (Scientific-technical Services UB), X. Solans (Crystallography Department UB), C. Puerta and P. Valerga (Cŕdiz Univesity), and L. Barrios (Inorganic Chemistry Section UB).
  • Cyclometallation reactions at Pd(II) and Pt(II) centres and  of oxidative addition reactions at Pt(II) centres: Reaction kinetics and activation parameters. Developed in collaboration with Drs M. Martínez (Inorganic Chemistry Section UB) and M. Gómez (Université Tolouse-3, Paul Sabatier).
  • Optical resolution of chiral phosphines by optically active cyclometallated palladium(II) compounds. Developed in collaboration with Drs G. Muller, D. Sainz and M. Rocamora (Inorganic Chemistry Section UB).
  • Electrochemistry of Pt(II) and Pt(IV) cyclometallated compounds. Developed in collaboration with Dr A. Klein (Institut für Anorganische Chemie der Universität Stuttgart) and C. López (Inorganic Chemistry Section UB).
  • Computational studies: Geometry optimization of Pd(II), Pt(II) and Pt(IV) molecular compounds and of cyclometallation reactions transition states at Pd(II) centres. Developed in collaboration with Drs R. Bosque and G. Aullón (Inorganic Chemistry Section UB).
  • Catalytic functionalization of C-H bonds by directing groups and Pd(0) or Pd(II) catalysts. Developed in collaboration with Drs J. García, X. Ariza, E. Nicolŕs and J. Farrŕs (Organic Chemistry Section UB).
  • In vitro anticancer activity of cyclometallated Pd(II), Pt(II) and Pt(IV) compounds: Cytotoxicity. Developed in collaboration with Drs M. Cascante (Biochemistry and Molecular Biomedicine Department UB), R. Messeguer (LEITAT) and J. Quirante (Pharmacology, Toxicology and Therapeutic Chemistry Department). Action on cell cycle arrest, apoptosis and ROS level (reactive oxygen species). Developed in collaboration with Drs M. Cascante (Biochemistry and Molecular Biomedicine Department UB) and J. Quirante (Pharmacology, Toxicology and Therapeutic Chemistry Department UB). Interaction with DNA and enzymes. Developed in collaboration with Drs L. Baldomŕ and J. Badia (Biochemistry and Physiology Department UB) and J. Quirante (Pharmacology, Toxicology and Therapeutic Chemistry Department).
  • Luminescent Pd(II), Pt(II) i Pt(IV) cyclometallated compounds. Developed in collaboration with Dr L. Rodríguez (Inorganic Chemistry Section UB).
  • Pd(II) cyclometallated compounds antibacterial and antioxidant activity in vitro. Developed in collaboration with Dr K. Khosa (GC University Faisalabad).
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